Which drugs or supplements interact with naproxen? Is naproxen safe to For EC-Naprosyn, the usual dose is mg twice daily. Naproxen should be. Mar 17, - Certain drugs are known to interact with naproxen and may cause problems: Naproxen may interact with several types of blood pressure medications and make them less effective. Some types of antacids medications may make naproxen less effective. Naproxen should be taken very carefully with other NSAIDs, including aspirin. medications are known to interact with naproxen. 85 major drug interactions ( brand and generic names); moderate drug interactions ( brand and generic names); 58 minor drug Pill Imprint IP (Naproxen mg).
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